Orthokeratotic hyperkeratosis (H&E, 40x). Additionally to the extraordinary thickening of the epidermis (achantosis), the cornified layer appears thickened, although its typical architecture has not changed and no nuclei can be seen in the cornified keratinocytes. This skin sample was collected from the back of a cow diagnosed with type 3 photosensitivity secondary to ingestion of hepatotoxic plants.

 

 

 
 
 
 
 

 

 
 
 
  
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